See more. Treatment involves immediately discontinuing the offending agent, aggressive supportive care to manage and prevent complications, and pharmacologic therapy in severe cases. 1,14,15 Quality of Life Working dogs are the canine muscle group: Malamutes, Portuguese Water Dogs, Saint Bernards, and Bernese Mountain Dogs. Diagnosis is suggested by the localization of the eruption and the history of exposure to an offending agent. (transitive) To hurt the feelings of; to displease; to make angry; to insult. With the understanding that this infection is a complication of antimicrobial therapy, an important therapeutic intervention is discontinuation of the offending drug when possible (52). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. offending definition: 1. unwanted, often because unpleasant and causing problems: 2. unwanted, often because unpleasant…. The rash usually burns, occurs on the face or the genitals, and, if the offending agent is given again, recurs in the same location. Often they are considered gentle giants. defend definition: 1. to protect someone or something against attack or criticism; to speak in favour of someone or…. Increased size of the clinical crown of a tooth by apical migration of the attachment epithelium and periodontium. The empiric medications most frequently used for refractory NMS include bromocriptine mesylate, a dopamine agonist, and dantrolene sodium, a muscle relaxant. The film became notorious because it took £89 [1] or £79 [2] at the box office. How the situation is handled (and by that I mean whether or not you should be writing under two separate names and/or keeping the material on the web site) is going to depend on the market you’re targeting and how graphic the pieces might be. It was directed by Andrew Rajan and starred Susannah Harker , Shaun Parkes and Michael Cochrane . Treatment includes removal of the offending agent in conjunction with use of anti-inflammatory steroid creams, antihistamines and, in severe cases, oral corticosteroids. Stopping the offending agent immediately, using systemic with tapering over 8 to 12 weeks, and topical, high-potency glucocorticoids can help. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … (Klaus MV, Wieselthier JS, Am Fam Physician 1993 Sep 15;48(4):629-632) At the first sign of renal dysfunction, the patient's medication list should be reviewed to identify offending agents. Learn more. Offend definition, to irritate, annoy, or anger; cause resentful displeasure in: Even the hint of prejudice offends me. Learn more. Simply discontinuing the offending agent may be the only intervention necessary in a small proportion of patients, generally those with mild infection (130). 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